New York Society for Applied Spectroscopy

"Raman and NIR: A Tale of Two Techniques for QC and Process Analysis"

Mark S. Kemper

Senior Applications Scientist, Kaiser Optical Systems

371 Parkland Plaza

Ann Arbor, MI 48103

One of the most convenient and effective means of performing QC and process analyses

involves the use of vibrational spectroscopy. Polymer and chemical companies have used spectroscopy for many years to control their processes.

With the current initiative for Process Analytical Technology (PAT), most pharmaceutical companies are also beginning to implement such measures for process control. Near-infrared (NIR) spectroscopy has been one of the primary techniques used over the past 15 years for these situations. More recently, Process Chemists and Engineers have discovered that Raman

spectroscopy can be used for this same purpose. The obvious question then becomes how the two compare with one another in real process situations. More often than not, the choice of technique is based on the predisposition of the practitioner. The two techniques share many advantages but each has its own strengths and weaknesses. This talk will examine the practical

aspects of process analytical applications using NIR and Raman. The results from the two techniques will be compared for several applications. Through these comparisons, some rules of thumb for selection will be suggested.

Speaker Bio

Mark Kemper earned a Bachelor Degree in Chemistry from the University of Dayton and a Masters Degree in Biological Chemistry from the University of Minnesota. He worked in the Pharmaceutical Industry for nine years at Upjohn, Boehringer Ingelheim, Warner-Lambert and Ben Venue Labs as an Analytical and Formulation Scientist employing various analytical techniques during the course of his tenure. In 1994, he decided to leave the pharmaceutical industry for the instrument business going to work for NIRSystems. There he concentrated on the application of Near Infrared Spectroscopy, particularly the use of the technique in the Pharmaceutical industry. In 1999, he moved to Nicolet to focus on Near Infrared and Raman spectroscopy. At the beginning of 2003, Mark moved to Kaiser Optical Systems where he now works as a Senior Applications Scientist supporting various

Raman applications in the Pharmaceutical, Polymer and Chemical industries.

He has eleven publications and more than 40 presentations at scientific

meetings that deal with the application of vibrational spectroscopic

techniques in the pharmaceutical industry as well as other industries.

Cul-Spec-Chrom-

Jerry DeMenna

Buck Scientific

Norwalk, Ct

Born Gerald John DeMenna on a Friday the 13th. in July during the mid-50s, in a half-Italian, half-Jewish community in northern New Jersey; "Jerry" showed his affinity for the Sciences at age 5 when he and his Dad grew "Rock Candy" crystals for a science fair, then he burned his hands at age 9 with a home-made Thermite experiment quite a transition! His culinary skills in the kitchen were started with his paternal Grandmother, at age 8; when she lovingly demonstrated the secret of true Neapolitan Italian "Gravy" (tomato sauce with meat to the average American). His multi-ethnic friendships gave him a worldly insight of other cuisine and cooking methods. Jerry enjoys his duties as a universal Scientist today.

He studied Pharmacy at Rutgers University Newark in the '70s and worked as a junior chef in NYC to pay his way through school, changing to get a Masters in Analytical Chemistry in the '80s, and receiving his Ph.D. in Organo-Metallic CATALYST Synthesis in '93 and an honorary Doctorate degree from the University of Perideniya in Sri Lanka during his extensive travels in 1996; sum up "Doctor DeMento's" high-tech academic and professional career with his current position at his private Research & Development Laboratory; Chem-Chek in the Bronx, NY.

He is currently the General & Laboratory Manager for BUCK Scientific, an analytical instrument manufacturer in Norwalk, CT; and is a free-lance Professor (for some reason can't get tenured???) at Sacred Heart University, CT; Juniata College, PA and various school around the country. He has a collection of various State Speeding Tickets suitable for submission to the Smithsonian. His love of science and the need to get more kids interested in REAL technology (not just computers) forced him to develop the FUN-SCIence program to show both Teachers and Students that Science, and in particular Chemistry, can indeed be FUN! With emphasis on consumer products, foods, etc.; there's always something to catch everybody's attention.

The World of FOOD TECHNOLOGY, and FOOD CHEMISTRY in particular; was revolutionized back in 1988 when some guy name Emeril Churchkey or is it Emil Churchak, was an Editorial Advisor for SPECTROSCOPY magazine and had the guts, nerve and testosterone to publish a technical article that began with the word MANGIARE! Thus the new Science of Culinary Spectroscopy began and has evolved into the fields of Chromatography, Electrochemistry and Molecular Biology as well! The purpose of the Culinary Sciences program is not for the benefit of the theoretical Scientist but for the home Chef that wants to make sure that their Beef Stroganoff or Shrimp Scampi or Baba Ganouj are better than good! Cooking is nothing more than Synthetic Organic Chemistry with edible Reagents, so why not understand the Reaction mechanisms of Sautéing or Frying to increase yields of favorable products? Come and see the Dynamics of Donuts, avoid the Fears of Failed French Fries and learn to Engineer a proper Etoufee.

Appetizer: Pasta Primavera

Salad: Caesar Salad

Entree:( *Choose One): Prime Rib of Beef

Chicken Amore - Boneless Chicken Breast in a white wine sauce with

sundried tomatos, artichoke hearts and roasted

peppers topped with Mozzarella cheese.

Dessert: Chef's choice , Coffee & Tea

*Please indicate your choice of entree when you RSVP

Double Tree Inn (Formerly Ramada Inn New York Steak House)

180 Rt. 17 South

Mahwah, NJ 07430

201-529-5880

Directions:

FROM THE GEORGE WASHINGTON BRIDGE

From the bridge take Rt. 80 W. to R. 17 N. Travel about 15 miles to Rt. 202 Exit in Mahwah. Take U-turn at Rt. 202. Get Back onto Rt. 17 S. The hotel is about 50 yards on the right.

FROM THE GARDEN STAE PARKWAY NORTHBOUND

Take Exit 163 onto Rt. 17N. Travel about 10 miles to the Rt. 202 Exit in Mahwah. Take the U-turn at Rt. 202. Get back onto 17S. The hotel is on the right.

FROM I-287

Take Exit #66 onto Rt. 17S. The hotel is on the right

FROM THE NEW YORK THRUWAY

Take Exit #15 Suffern to Rt. 17S. The hotel is 1 mile on the right.

FROM NEWARK AIRPORT

Take the N.J Turnpike North to Exit #16W.to Rt. 3 West to Rt. 17 N to the Route 202 Exit in Mahwah. Take the U-turn at Rt. 202 Get back onto Rt. 17S. The hotel is on the right.

FROM KENNEDY AIRPORT

Take the Van Wyck Expressway to Grand Central Parkway to Triboro Bridge to the Thruway north to Exit #15 onto Rt. 17S. The hotel is 2 miles from the NY State Thruway.

FROM LAGUARDIA AIRPORT

Take the Grand Central Parkway to the Triboro Bridge to the Thruway North to Exit # 15 for Rt. 17 S. The hotel is 2 miles from the NY State Thruway.

Double Tree Inn

180 Rt. 17 South

Mahwah, NJ 07430

Directions:

FROM THE GEORGE WASHINGTON BRIDGE

From the bridge take Rt. 80 W. to R. 17 N. Travel about 15 miles to Rt. 202 Exit in Mahwah. Take U-turn at Rt. 202. Get Back onto Rt. 17 S. The hotel is about 50 yards on the right.

FROM THE GARDEN STAE PARKWAY NORTHBOUND

Take Exit 163 onto Rt. 17N. Travel about 10 miles to the Rt. 202 Exit in Mahwah. Take the U-turn at Rt. 202. Get back onto 17S. The hotel is on the right.

FROM I-287

Take Exit #66 onto Rt. 17S. The hotel is on the right

FROM THE NEW YORK THRUWAY

Take Exit #15 Suffern to Rt. 17S. The hotel is 1 mile on the right.

FROM NEWARK AIRPORT

Take the N.J Turnpike North to Exit #16W.to Rt. 3 West to Rt. 17 N to the Route 202 Exit in Mahwah. Take the U-turn at Rt. 202 Get back onto Rt. 17S. The hotel is on the right.

FROM KENNEDY AIRPORT

Take the Van Wyck Expressway to Grand Central Parkway to Triboro Bridge to the Thruway north to Exit #15 onto Rt. 17S. The hotel is 2 miles from the NY State Thruway.

FROM LAGUARDIA AIRPORT

Take the Grand Central Parkway to the Triboro Bridge to the Thruway North to Exit # 15 for Rt. 17 S. The hotel is 2 miles from the NY State Thruway.